<p>Cupramine is superior to copper sulfate, chloride & citrate: it is non-acidic, less toxic to fish, remains in solution, and does not contaminate the filter bed. It is superior to chelates: it is fully charged (ionic), and active at low concentrations, and is removable with carbon. <p><p>DIRECTIONS: Remove all invertebrates. Turn off UV sterilizer; remove chemical filtration. Use 2 drops per 4 L (1 gallon*) the first day, wait 48 hours, then repeat for a total dose of 0.5 mg/L (in freshwater, use half dose). Leave at this concentration for 14 days. Do not redose without testing (MultiTest: Copper). Do not use in conjunction with any other medication. If tank has ever been treated with an ionic copper, test copper level after initial dosing. Although most fish toler